Anticancer therapy–induced autophagy can trigger adaptive drug resistance in a variety of cancer types and treatments. However, BRAF-mutant thyroid cancer is relatively resistant to vemurafenib, and the reason for this disparity remains unclear. Wang, Weibin Kang, Helen Zhao, Yinu Min, Irene Wyrwas, Brian Moore, Maureen Teng, Lisong Zarnegar, Rasa Jiang, XuejunĬontext: The RAF inhibitor vemurafenib has provided a major advance for the treatment of patients with BRAF-mutant metastatic melanoma. Targeting Autophagy Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib If validated in other studies, risk of infection should be considered when applying corticosteroids in combination with BRAF inhibitors, in particular vemurafenib. Our findings demonstrate a significant lymphopenia in patients treated with the BRAF inhibitor vemurafenib, which is further augmented by dexamethasone and predisposes to infection. All 9 cases with infections demonstrated lymphopenia, 8 of these had received dexamethasone and 7 of these a therapy with vemurafenib. In our cohort, infections were noted in 9 patients, 4 of these were severe and 2 eventually fatal. Lymphopenias were observed in 84.6% of patients receiving vemurafenib and dexamethasone. Dexamethasone co-administration further diminished lymphocyte counts.
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Dabrafenib treated patients only rarely demonstrated lymphopenia (12.5%). Vemurafenib treatment led to a considerable decrease in lymphocyte cell counts, with 62.3% of patients having lymphopenia. Additionally, the number and severity of infections occurring in these groups was analyzed. The amount of patients receiving either medication with or without systemic corticosteroids (dexamethasone) was determined and lymphocyte counts before and under therapy assessed. A cohort of 102 patients receiving either the selective BRAF inhibitor vemurafenib or dabrafenib was analyzed. In the current study, the extent to which concomitant use of corticosteroids in BRAF inhibitor treated patients affects lymphocyte counts and predisposes to infection was investigated. We have previously demonstrated an impact of the BRAF inhibitor vemurafenib on patient lymphocyte counts. Sondermann, Wiebke Griewank, Klaus G Schilling, Bastian Livingstone, Elisabeth Leyh, Julia C Rompoti, Natalia Cosgarea, Ioana Schimming, Tobias Schadendorf, Dirk Zimmer, Lisa Hillen, Uwe Be sure and check out the Early Americana Ephemera sets, met here and here.Corticosteroids augment BRAF inhibitor vemurafenib induced lymphopenia and risk of infection. Go GREEN with this AfterFX template and give your media an. Sin Out is a playful handwritten font duo, this font very simple and easy to use.
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